Although topical cream is being considered as the best cure for yeast infection and to be highly effective at treating the symptoms, they however do not actually aid in treating the underlying cause of the infection. In most cases, the only certain way of curing the yeast infection is to essentially make use of the topical cream in combination with medication taken orally as well. The topical cream will work in eliminating the pathogenic fungi on the surface of the skin while the oral medication will work by getting rid of the infection-causing microorganisms inside one’s body. Together, the combination of topical cream and oral medicine should be the best yeast infection treatment.